| Wed, Apr 1 | vs Bellarmine Knights | 10:00 PM | Tri-State Orthopaedics Field at James & Dorothy Cooper Stadium |
| Fri, Apr 3 | vs Northern Iowa Panthers | L 2–5 | Tri-State Orthopaedics Field at James & Dorothy Cooper Stadium |
| Fri, Apr 3 | vs Northern Iowa Panthers | W 10–7 | Tri-State Orthopaedics Field at James & Dorothy Cooper Stadium |
| Sat, Apr 4 | vs Northern Iowa Panthers | 4:00 PM | Tri-State Orthopaedics Field at James & Dorothy Cooper Stadium |
| Tue, Apr 7 | @ Southern Illinois Salukis | L 0–9 | Charlotte West Stadium |
| Tue, Apr 7 | @ Southern Illinois Salukis | L 0–8 | Charlotte West Stadium |
| Tue, Apr 14 | vs Southeast Missouri State Redhawks | 9:00 PM | Evansville, Ind. |
| Wed, Apr 15 | vs Western Kentucky Hilltoppers | L 5–7 | Evansville, Ind. |
| Fri, Apr 17 | @ Bradley Braves | 7:30 PM | Peoria, Ill. |
| Sat, Apr 18 | @ Bradley Braves | 7:00 PM | Peoria, Ill. |
| Tue, Apr 21 | @ Northern Kentucky Norse | 8:00 PM | Frank Ignatius Grein Softball Field |
| Fri, Apr 24 | @ UIC Flames | 9:00 PM | Flames Field |
| Sat, Apr 25 | @ UIC Flames | 6:00 PM | Flames Field |
| Wed, Apr 29 | @ Indiana Hoosiers | L 0–8 | Andy Mohr Field - Softball |